Study of Kohzaburo 1963 Shimizu-higashi high school of Shizuoka prefecture (in the chemistry club) 16 The qualitative cation analysis of stones in riverbed of Ihara. Yamamoto Kohzaburo, (1963) The production of Zinc sulfide/copper phosphorescent powder. Yamamoto Kohzaburo, (1964) (Left photograph) The synthesis of fluorescein by phthalic anhydride-resorcinol dehydration and the pH dependence of fluorescence. Suzui Keiko and Yamamoto Kohzaburo, (1964-5) (Right photograph) . 1966 Hokkaido Univ. (in the laboratory of liberal arts) 19 The study of red chemiluminescence on chlorine bubble surface in 30% hydrogen peroxide/sodium hydroxide solution. Yamamoto Kohzaburo, (1966-7) . 1968 Hokkaido Univ., school of 2nd chemistry (in div. of chemistry, Res. Inst. Applied Electricity) 21 The measurement of Intersystem-crossing quantum yield of phthalazine using Triplet-Triplet energy transfer. Yamamoto Kohzaburo, (1969) . 1970 Hokkaido Univ. master's course of chemistry (Res. Inst. of Applied Electricity, div. of chemistry) 23 (1) Intersystem crossing quantum yield of phthalazine. Takemura T., Yamamoto K. Yamazaki I. and Baba H., Bull. Chem Soc. Japan, 45: 1639-1642, 1972 . 1972 Hokkaido Univ. doctor's course of chemistry (Institute of applied electricity, div. of chemistry) 25 (2) Measurement of Singlet-Triplet absorption spectrum of pyridazine by a sensitized-phosphorescence excitation method. Yamamoto K. Takemura T. and Baba H., Bull. Chem Soc. Japan, 48: 2599-2600, 1975. (3) Dynamical study of Triplet-Triplet energy transfer in rigid solution. Yamamoto K. Takemura T. and Baba H., J. Luminescence, 15: 445-454, 1977. (4) Spectroscopic studies on triplet-triplet energy transfer between aromatic compounds in rigid solution. Yamamoto K., Thesis, pp1-133, Sapporo, 1977. . 1977 degree of Ph. D., marriage and Riko Trading Co. (Academic div.) 30 (5) Fluorescence and dual phosphorescence spectra of quinoxaline in fluid solution. Yamamoto K. Takemura T. and Baba H., Bull. Chem Soc. Japan, 51: 729-732, 1978. . 1980 Kanazawa Medical University, assistant (Central Laboratory) 33 (6) The effect of maternal antigenic stimulation on the immune response of their offspring. II. Determination of suppressive site. Shimuzu S, Hara A, Miura Y, Watanabe Y, yamaguchi N, Saito T, Inoue M, Fujikawa K and Yamamoto M., J. Kanazawa Med. Univ., 6: 241-246, 1981. (7) RNA dependence in the cell cycle of V79 cells. Fujikawa-Yamamoto K., J. Cell. Physiol., 112: 60-66, 1982 (8) The relation between length of the cell cycle duration and RNA content in HeLa S3 cells. Fujikawa-Yamamoto K., Cell Struct. Funct., 8: 303-308, 1983 (9) Flow cytometry and the example of applications. Fujikawa K., Ann. Rep. Tech. Div. Natl. Inst. Physiological Sci., 5: 11-13, 1983. (10) Flow cytometry of the phagocytosis of fluorescent microspheres in V79 cells. Fujikawa-Yamamoto K. and Wada M., Cell Struct. Funct., 8: 373-377, 1984 (11) A method for the cell cycle analysis by a microcomputer. Fujikawa-Yamamoto K., J. Kanazawa Med. Univ., 9: 105-112, 1984 (12) Machinery(Cytofluorograf). Fujikawa-Yamamoto K. and Takamoto S., in Flow Cytometry -protocols and practice, Ohta K and Nomura k. eds., pp543-551, Kani-shobo, Tokyo, 1984. (13) Maintenance and refinement of Cytofluorograf System 50H. Fujikawa-Yamamoto K., Flow Cytometry, 1: 6-9, 1984. . 1985 Kanazawa Medical University, lecturer (Central Laboratory) 38 (14) Shortening of S phase after hydroxyurea treatment. Okada T., Yamada N. and Fujikawa-Yamamoto K. J. Kanazawa Med. Univ., 10: 1-5, 1985 (15) Cell cycle dependency of the phagocytosis of microspheres in 3T3 cells. Fujikawa-Yamamoto K., Murakami E., Odashima S., Inoue M. and Kurihara T. J. Kanazawa Med. Univ., 10: 6-11, 1985 (16) An improved method of cell cycle analysis by a microcomputer and the examination utilizing anti-BrdU monoclonal antibody. Fujikawa-Yamamoto K., Murakami E., and Odashima S. J. Kanazawa Med. Univ., 10: 12-17, 1985 (17) A method for cell cycle analysis by a microcomputer for regenerating rat liver cells. Fujikawa-Yamamoto K., Matsuda T., Odashima S. and Murakami E. J. Kanazawa Med. Univ., 10: 249-256, 1985 (18) A study for cell cycle analysys I.-examination using anti BrdU monoclonal antibody-. Fujikawa-Yamamoto K. Flow Cytometry, 3: 25-26, 1985. (19) A study for cell cycle analysys I.-aplication to regenerating rat liver-. Fujikawa-Yamamoto K., Matsuda T. and Odashima S. Flow Cytometry, 3: 27-28, 1985. (20) Flow cytometric determination of cell cycle parameters of V79 cells by continuous labeling with bromodeoxyuridine. Fujikawa-Yamamoto K., Miyashita N. and Odashima S. Cell Struct. Funct., 11: 115-124, 1986 (21) Evaluation of the phagocytosis of microspheres in V79 cells by flow cytometry. Fujikawa-Yamamoto K., Yokoe H. and Odashima S. Cell Struct. Funct., 12: 83-91, 1987 (22) DNA synthesis in Bloom's syndrome fibroblasts. Fujikawa-Yamamoto K., Odashima S., Kurihara T. and Murakami E. Cell Tissue Kinet., 20: 69-76, 1987 (23) Coefficient of variation in Flow cytometry of phagocytosis. Fujikawa-Yamamoto K., and Odashima S. Cytometry, 8: 104-106, 1987 (24) Different responses in the cell cycle of tumor cells to ginsenoside Rh2. Fujikawa-Yamamoto K., Ota T., Odashima S., Abe H. and Arichi S. Cancer J., 1: 349-352, 1987 (25) Plant-glycoside modulation of cell surface related to control of differentiation in cultured B16 melanoma cells. Ota T, Fujikawa-Yamamoto K., Zong Z., Yamazaki M., Odashima S., Kitagawa I., Abe H. and Arichi S. Cancer Res., 47: 3863-3867, 1987 (26) Effects of glycyrrhizin and glycyrrhetinic acid on growth and melanogenesis in cultured B16 melanoma cells. Abe H., Ohya N., Fujikawa-Yamamoto K., Shibuya T., Arichi S. and Odashima S. Eur. J. Cancer Clin. Oncol., 23: 1549-1555, 1987 (27) Bloom's syndrome has faults in the early stage of DNA synthesis. -Deficiency of DNA ligase I leads disease?-. Fujikawa K. Igakuno Ayumi, 141: 915, 1987 (28) The CV value of fluorescent spheres localized in cells. Fujikawa-Yamamoto K., Odashima S. and Yokoe H. Flow Cytometry, 6: 48-51, 1987. (29) Deficiency of DNA ligase I. Fujikawa K. Rinsyo Kensa, 32: 787, 1988. (30) Effects of colcemid in a low concentration on several cultured cells. Yokoe H. and Fujikawa-Yamamoto K. Flow Cytometry, 7: 55-58, 1988. (31) Effects of Ginsenoside Rh2 on cell cycle of B16 melanoma and Meth-A cells. Fujikawa-Yamamoto K., and Odashima S. Flow Cytometry, 7: 82-85, 1988. (32) Basic study for FCM measurements of phagocytic activity. Fujikawa-Yamamoto K., Ishii E. and Odashima S. Flow Cytometry, 8: 110-113, 1988. . 1989 Kanazawa Medical University, associate professor (Res. Inst. of Med. Sci., division of Basic Science) 42 (33) Synergistic effects of hydroxyurea and thymidine on the growth inhibition of V79 cells. Fujikawa-Yamamoto K. and Odashima S. Cell Struct. Funct., 14: 399-405, 1989 (34) Effects of hydroxyurea on the phagocytosis of microspheres in V79 cells. Fujikawa-Yamamoto K., Yokoe H. and Odashima S. Cell Struct. Funct., 14: 485-493, 1989 (35) FCM measurements of chromosomes in Kanazawa Medical University. Fujikawa-Yamamoto K. and Odashima S. Flow Cytometry, 9: 21-24, 1989. (36) FCM analyses of phagocytic activity in cultured V79 cells. Fujikawa-Yamamoto K. Ota T. and Odashima S. Flow Cytometry, 9: 43-46, 1989. (37) Induction of phenotypic reverse transformation by plant glycosides in cultured cancer cells. Odashima S., Ota T., Fujikawa-Yamamoto K. and Abe H. Jpn. J. Cancer Chemother., 16: 1483-1489, 1989 (38) The adjustment for cell sorting (Ortho). Fujikawa-Yamamoto K. in The Introduction of Flow Cytometry , Kawamoto K and Akagi k. eds., pp21-24, Igaku-shobo, Tokyo, 1989. (39) The cell cycle analysis of regenerating rat liver. Fujikawa-Yamamoto K. and Odashima S. in The Introduction of Flow Cytometry , Kawamoto K and Akagi k. eds., pp224-226, Igaku-shobo, Tokyo, 1989. (40) Is cancer irreversible? Odashima S., Fujikawa-Yamamoto K. and Tanino M. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 1: 3-19, 1989. (41) Non tumor cells in malignant Hodgikin lymphoma. Tanino M., Fujikawa-Yamamoto K. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 1: 34-41、1989. (42) Relatinship between the response to colcemid and c-myc oncogene protein in cultured cells. Fujikawa-Yamamoto K. Teraoka K., Miyagoshi M. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 1: 42-49、1989 . (43) Relationship between the response to colcemid and the c-myc oncoprotein in cell lines. Fujikawa-Yamamoto K. and Odashima S. Flow Cytometry, 10:86-91, 1990. (44) Association between PNA binding property and metastatic ability in mouse melanoma cells. Maeda M, Ota T., Kohno H., Odashima S. and Fujikawa-Yamamoto K. Flow Cytometry, 10:92-97, 1990. (45) Induction of phenotypic reverse transformation by ginsenoside in cultured cells. Ota T., Fujikawa-Yamamoto K., Kohno H. and Odashima S. Korean J. Ginseng Sci., 14: 238-243, 1990 (46) Histological grade of non-Hodgikin's lymphomas according to the DNA ploidy and immunohistochemistry. Tanino M., Go K., Fujikawa-Yamamoto K. Ota T. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 2: 29-35, 1990. (47) Study of cell cycle regulation mechanism.-cell cycle analysis for depressed rate of DNA synthesis-. Fujikawa-Yamamoto K. Tanino, M., Teraoka, K., Miyagoshi M. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 2: 36-43, 1990. (48) Changes in c-myc oncogene protein in demecolcin-induced polyploidization of B16F10, V79 and Meth-A cells. Fujikawa-Yamamoto K. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 2: 44-53, 1990. (49) Different resistancy to RNase in cultured cells. Fujikawa-Yamamoto K. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 2: 54-59, 1990. (50) Different expression of c-myc protein in the addition of differentiation inducer to Meth-A and 3LL cells. Fujikawa-Yamamoto K. Maeda M., Ota T. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 2: 60-65, 1990. (51) Different response to PMA treatment in HL60 and Meth-A cells. - on the phagocytic activity -. Fujikawa-Yamamoto K. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 2: 66-70, 1990. (52) Standard value in measurement of Na/K ATPase of human red blood cells membrane. Teraoka K., Miyagoshi M., Fujikawa-Yamamoto K., Odashima S., Sugita T., Asaji T., Matsui S., Turitani I. and Yamada Y. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 2: 75-82, 1990. (53) Development of dynamical measurement of phagocytic activity using flow cytometry. Fujikawa-Yamamoto K. Research Report to the Ministry of education (C) ,1990. (54) Self-consistent cell cycle analysis and the application to Bloom's syndrome fibroblasts. Fujikawa-Yamamoto K., Tanino M. and Odashima S. Flow Cytometry and Image Analysis for Clinical Applications (I. Nishiya, L. S. Cram and J. W. Gray ed.) 187-192, Excepta Medica, Amsterdam, 1991. (55) The role of host cells in tissue of malignant B lymphoma. Tanino M., Ota T., Kohno H., Fujikawa-Yamamoto K. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 3: 61-67, 1991. (56) Study of cell cycle regulation mechanism.-A probability of restriction point in M phase-. Fujikawa-Yamamoto K., Tanino M., Teraoka K. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 3: 68-71, 1991. (57) Basic study for ACAS570, a confocal laser microscope. Teraoka K., Fujikawa-Yamamoto K. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 3: 72-77, 1991. (58) Effects of benzalkonium chloride on the cell cycle.-flow cytometric analysis-. Takahashi n., Fujikawa-Yamamoto K., Miyagoshi M., Teraoka K. and Taniuchi K. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 3: 105-107, 1991. (59) Determination of human erythrocyte membrane Na+/K+ ATPase activity in small volume of blood sample. Teraoka k., Miyagoshi M., Fujikawa-Yamamoto K., Odashima S., Sugita T., Asaji T., Matsui S., Tsuritani I., Honda T. and Yamada Y. Jpn. J. Clin. Pathol., 40: 410-416, 1992. (60) A flow cytometric study of the effects of benzalkonium chloride on the cell cycle. Takahashi N., Fujikawa-Yamamoto K., Miyagoshi M., Teraoka K. and Taniuchi K. Acta Soc. Opthalmol. Jpn., 96: 823-827, 1992. (61) A basic study for the measurements of DNA fluorescence by a confocal laser cytometer, ACAS570 system. Teraoka K., Fujikawa-Yamamoto K. and Odashima S. J. Kanazawa Med. Univ., 17: 451-456, 1992. (62) Lynphocyte , HLA-DR expression and menstruation period in uterus. Tanino M.,Kohno H., Ota T., Fujikawa-Yamamoto K., Odashima S. and Takabayashi H. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 4: 31-37、1992. (63) A study of cell cycle reguraltion on tumor cells.-control points for polyploidization in Meth-A and B16F10 cells-. Fujikawa-Yamamoto K., Iwai H., Murakami E. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 4: 38-40、1992. (64) A basic study for the confocal measurements by ACAS 570. Teraoka K., Fujikawa-Yamamoto K. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 4: 41-45, 1992. (65) Cytotoxic effects of diclofenac sodium. Takahashi N., Miyagoshi M., Taka N., Kurihara T. and Fujikawa K. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 4: 70-73, 1992. (66) Cytological analysis of cholangiocarcinoma and bile duct epithelial cells - A model and search of phathological changes. Kinami Y.、Miyagoshi M. Yamagishi H., Yamashita M. and Fujikawa-Yamamoto K. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 4: 116-121, 1992. (67) Cytotoxic effects of diclofenac sodium. Takahashi N., Miyagoshi M., Taka N., Kurihara T. and Fujikawa K. Acta Soc. Opthalmol. Jpn., 97: 145-149, 1993. (68) Typing of responses of cultured cells to demecolcine and critical control points in the M phase. Fujikawa-Yamamoto K., Iwai H., Teraoka K., Odashima S. and Murakami E. J. Kanazawa Med. Univ., 18: 98-105, 1993 (69) Study on hyperploidization and the characteristics in cultured cells. Iwai H., Murakami E. and Fujikawa-Yamamoto K. J. Kanazawa Med. Univ., 18: 146-159, 1993. (70) Hyperploidization of V79 cells by K-252a in comparison with demecolcine. Fujikawa-Yamamoto K., Teraoka K. and Odashima S. Cell Struct. Funct., 18: 449-455, 1993 (71) The practice and attention in FCM measurements. Fujikawa-Yamamoto K. in The Introduction to Flow Cytometry , Sugishita M., Takamoto S., Nakahara K. and Nomura K. eds., pp32-35, Topuko, Tokyo, 1993. (72) Toxic effects of norfloxacin on cultured cells. Takahashi N., Miyagoshi M., Kurihara T., Murayama T. and Fujikawa-Yamamoto K. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 5:61-64、1993(other) (73) Hyperploidization of V79 cells. Fujikawa-Yamamoto K., Zong Z., Teraoka K., Yamagishi H., Kinami Y. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 5:65-75、1993(other) (74) Evidence for a a and b subunit isoform of Na, K-ATPase in human red blood cell membrane. Teraoka K., Fujikawa-Yamamoto K., Mathui S., Nagao Y., Takegami T. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 5:155-160、1993. (75) Prolongation of rat skin allograft survival induced by topical cyclosporin A ointment. Zong Z., Fujikawa-Yamamoto K., Teraoka K., Yamagishi H., Tanino M., Kinami Y., Igarashi R. and Mizushima H. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 5:184-189、1993. (76) Cytological analysis of cholangiocarcinoma and bile duct epithelial cells - An influence of bile acid lode on nuclear DNA of diisopropanolnitrosamine-induce bile duct epithelial cells. Kinami Y.、Miyagoshi M. and Fujikawa-Yamamoto K. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 5:204-212、1993. (77) Hyperploidization of Meth-A cells and B16F10 cells by K-252a and staurosporine. Fujikawa-Yamamoto K., Zong Z., Teraoka K., Yamagishi H. and Odashima S. Cytometry Res., 4: 29-33, 1994 (78) Apoptosis by demecolcine in V79 cells. Fujikawa-Yamamoto K., Teraoka K., Zong Z, Yamagishi H. and Odashima S. Cell Struct. Funct., 19: 391-396, 1994 (79) Potentiation of K-252a, a protein kinase inhibitor-induced polyploidization by cAMP in cultured fibrosarcoma cell line. Zong Z., Fujikawa-Yamamoto K., Teraoka K., Yamagishi H., Tanino M. and Odashima S. Biochem. Biophys, Res. Commun., 205: 746-750, 1994 (80) On the Ortho Cytofluorograf. Fujikawa-Yamamoto K. in The Chemistry and Biology Experimental line 33 , Ohkuma K. eds., pp140-148, Hirokawa, Tokyo, 1994. (81) Chromosome analysis and sorting. Fujikawa-Yamamoto K. in The Chemistry and Biology Experimental line 33 , Ohkuma K. eds., pp149-163, Hirokawa, Tokyo, 1994. (82) Nuclear associated antigen. Fujikawa-Yamamoto K. in The Chemistry and Biology Experimental line 33 , Ohkuma K. eds., pp211-228, Hirokawa, Tokyo, 1994. (83) Inhibitory effect of PMA on colcemid-induced polyploidy formation in Meth-A cells. Zong Z., Fujikawa-Yamamoto K., Tanino M., Teraoka K., Yamagishi H., Kinami Y. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 6: 56-62、1994. (84) Apoptosis by demecolcine (colcemid). Fujikawa-Yamamoto K., Teraoka K., Kurihara T., Zong Z, Miyagoshi M., Yamagishi H., Kinami Y. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 6: 93-102、1994. (85) Cytological analysis of cholangiocarcinoma and bile duct epithelial cells - An immunohistochemical study on the expression of P53 protein. Miyagoshi M、Kinami Y.、Fujikawa-Yamamoto K., Yamagishi H. and Tachibana H. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 6: 163-168, 1994. (86) Changes of lymphocyte numbers and their subsets in the peripheral blood of women during pregnancy. Tanino M., Ota T., Kohno H., Zong Z., Fujikawa-Yamamoto K., Odashima S. and Takabayashi H. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 6:178-181、1994. (87) Hyperploidization of B16BL6 cells by K-252a in comparison with staurosporine and demecolcine. Fujikawa-Yamamoto K., Teraoka K., Zong Z, Yamagishi H. and Odashima S. Cytometry Res., 5: 21-25, 1995. (88) The important role of PKC in controlling polyploidy formation in cultured fibrosarcoma cell line. Zong Z., Fujikawa-Yamamoto K., Tanino M., Teraoka K., Yamagishi H., Gai G. and Odashima S. Biochem. Molecular Biol. Intern., 35: 1009-1015, 1995. . 1996 Kanazawa Medical University, professor (Res. Inst. of Med. Sci., division of Basic Science) 49 (89) Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity. Zong Z., Fujikawa-Yamamoto K., Tanino M., Teraoka K., Yamagishi H. and Odashima S. Biochem. Biophys, Res. Commun., 219: 480-485, 1996 (90) Fraction of proliferating cells in maturation process of mouse heart. Fujikawa-Yamamoto K. and Iwai H. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 7: 104-112, 1996. (91) Subsets and distribution of mononuclear cells appearing in the decidua in pregnancy. Tanino M., Ota T., Kohno H., Zong Z., Fujikawa-Yamamoto K., Odashima S. and Takabayashi H. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 7: 113-116, 1996. (92) Cytological analysis of cholangiocarcinoma and bile duct epithelial cells - Influence of bile acid load on DNA distribution pattern of diisopropanolnitrosamine-induced proliferated bile ductules and cholangiocarcinoma in hamsters. Kinami Y., Miyagoshi M. and Fujikawa-Yamamoto K. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 7: 75-84, 1996. (93) Polyploidization and its character changes. Fujikawa-Yamamoto K., Kinami Y. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 7: 21-47, 1996. (94) Induction of characteristics alteration in cancer cells. Odashima S., Tanino M. and Fujikawa-Yamamoto K. J. Kanazawa-Med. Univ., 20: 475-485, 1996. (95) Influence of bile acid load on the DNA distribution pattern of proliferated bile ductules and cholangiocarcinomas induced by diisopropanolnitrosamine in hamster. Kinami Y., Miyakoshi M. and Fujikawa-Yamamoto K. Recent advances in gastroenterological carcinogenesis I. (E. Tahara, K. Sugimachi and T. Oohara ed.) 701-705, Monduzzi Editore, Bologna (Italy), 1996. (96) Detection of 92 kD Na, K-ATPase α1 subunit-like protein in human red blood cell membrane and its partial purification. Teraoka K., Fujikawa-Yamamoto K., Miyakoshi M. et al. Histochem. Cytochem. 1996 (T. Saito ed.) 890-891, 1996, Jpn. Soc. Histochem. Cytochem. Kyoto. (97) The effect of bile acid load on cell nuclear DNA content in the lesions of proliferated bile duct epithelium and cholangiocarcinoma induced by diisopropanolnitrosamine in hamsters -cytofluorometric analysis-. Miyakoshi M., Fujikawa-Yamamoto K., Teraoka K. et al. Histochem. Cytochem. 1996 (T. Saito ed.) 533-534, 1996, Jpn. Soc. Histochem. Cytochem. Kyoto. (98) Spontaneous polyploidization results in apoptosis in a Meth-A tumor cell line. Fujikawa-Yamamoto K., Zong Z, Murakami M., Odashima S., Ikeda R., and Yoshitake Y. Cell Struct. Funct., 22: 399-405, 1997. (99) Different manner of DNA synthesis in polyploidizations of Meth-A and B16F10 cell lines. Fujikawa-Yamamoto K., Zong Z, Murakami M. and Odashima S. Cell Struct. Funct., 22: 527-532, 1997. (100) Effect of demecolcine on the three sub-lines of B16 melanoma cells. Fujikawa-Yamamoto K., Gai G., Zong Z., Murakami M., Yamagishi H., and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 8: 84-93, 1997. (101) Cytological analysis of cholangiocarcinoma and bile duct epithelial cells - Influence of bile acid load on nuclear area and PCNA expression in diisopropanolnitrosamine-induced proliferated bile ductule lesion and cholangiocarcinomas in hamsters. Miyagoshi M., Kinami Y. and Fujikawa-Yamamoto K. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 8: 108-119, 1997. (102) Bile acid load on the DNA distribution pattern of bile ductules and cholangiocarcinoma induced by diisopropanolnitrosamine in hamsters. Kinami, Y., Miyakoshi, M. and Fujikawa, K. Oncology, 55: 77-86, 1998. (103) Apoptotic cell death of high polyploid cells in a cultured sarcoma cell line. Zong Z, Fujikawa-Yamamoto K., Ota T., Guan X, Murakami M., Li A., Yamaguchi N., Tanino N and Odashima S. Cell Struct. Funct., 23: 231-237, 1998. (104) Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells. Zong Z, Fujikawa-Yamamoto K., Ota T., Guan X, Murakami M., Li A., Yamaguchi N., Tanino N and Odashima S. Cell Struct. Funct., 23: 265-272, 1998. (105) Staurosporine inhibits the polyploidization of Meth-A cells by demecolcine. Fujikawa-Yamamoto K., Zong Z, Murakami M., Guan X. and Ohdoi C. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 9: 119-124, 1998. (106) Responses of HL60, EL4 and B16F10 cell-lines to demecolcine. Fujikawa-Yamamoto K., Zong Z, Murakami M., Yamagishi H., Guan X. and Ohdoi C. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 9: 101-107, 1998. (107) Cyclic AMP potentiates polyploidization induced by K-252a in cultured fibrosarcoma cell line. Zong Z, Fujikawa-Yamamoto K., Guan X, Murakami M. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 9: 158-164, 1998. (108) Lack of synchrony among multiple nuclei induces partial DNA fragmentation in V79 cells polyploidized by demecolcine. Fujikawa-Yamamoto K., Ohdoi C., Yamagishi H., Zong Z., Murakami M. and Yamaguchi N Cell Prolif., 32: 337-349, 1999. (109) A comparison of Cell-Disk and Chamber-Slide for the LSC measurements of V79 cells. Yamagishi H., Fujikawa-Yamamoto K., Zong Z., Murakami M. and Ohdoi C. Cytometry Res., 9: 23-27, 1999. (110) Cell cycle responses of EL4 cells to demecolcine, staurosporine and K-252a. Fujikawa-Yamamoto K. and Odashima S. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 10: 103-112, 1999. (111) Polyploidization of Meth-A cells by Taxol is enhanced by PMA. Guan X, Fujikawa-Yamamoto K., Zong Z, Murakami M, Yamagishi H and Ohdoi C. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 10: 64-77, 1999. (112) Both low and high concentration of staurosporine induce G1 arrest through down regulation of cyclin E and cdk2 expression. Zong Z., Fujikawa-Yamamoto, K., Li A., Chang Y, Murakami M, Odashima S and Ishikawa Y. Cell Struct. Funct., 24: 457-463, 1999. (113) Cell-cycle analysis of DNA histograms in logarithmic scale. << Source Program >> Fujikawa-Yamamoto K. Cytometry Res., 9: 73-84, 1999. (114) DNA ploidy analysis of urinary tract epithelial tumors by laser scanning cytometry. Kawamura K., Tanaka T., Ikeda R., Fujikawa-Yamamoto K. and Suzuki K. Anal. Quant. Cytol. Histol., 22: 26-30, 2000. (115) Cell membrane changes of structure and function in protein kinase inhibitor-induced polyploid cells. Zong Z., Fujikawa-Yamamoto K., Li A., Yamaguchi N., Chang Y., Murakami M., Tanino N and Odashima S. Cell Prolif., 33: 29-38, 2000. (116) Different responses of polyploid V79 cells after removal of two drugs, demecolcine and K-252a. Fujikawa-Yamamoto K., Yamagishi H., Zong Z., Ohdoi C, and Wang S. Cell Struct. Funct., 25: 41-46, 2000. (117) Involvement of protein kinase C in taxol-induced polyploidization in a cultured sarcoma cell line. Zong Z., Fujikawa-Yamamoto K., Li A., Yamaguchi N., Chang Y, Murakami M, and Ishikawa Y. Eur. J. Pharmacol., 394: 181-187, 2000. (118) Intranuclear localization of proliferating cell nuclear antigen during the cell cycle in renal cell carcinoma. Kawamura K., Kobayashi Y, Tanaka T., Ikeda R., Fujikawa-Yamamoto K. and Suzuki K. Anal. Quant. Cytol. Histol., 22: 107-113, 2000. (119) Polyploidization of K562 cells by demecolcine, K-252a and staurosporine. Fujikawa-Yamamoto K., Yamagishi H., Zong Z., Ohdoi C. and Wang S. Cytologia, 65:203-209, 2000. (120) Cell-cycle response-analysis of polyploid cells. Fujikawa K. Saibou (The Cell), 32: 169-172, 2000. (121) Effect of caffein to the cell cycle of diploid and tetraploid Meth-A cell lines. Fujikawa K., Yamagishi H., Wang S., Miyakoshi M., Murano H., Ikeda T. and Zong Z. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 11: 58-64, 2000. (122) Lectin binding in Meth-A cells polyploidized by different mechanisms. Fujikawa-Yamamoto K., Ohdoi C., Yamagishi H., Zong Z. and Wang S. Cytologia, 65:389-395, , 2000. (123) Establishment of a tetraploid Meth-A cell line through polyploidization by demecolcine not by staurosporine, K-252a and paclitaxel. Fujikawa-Yamamoto K., Wang S., Yamagishi H., Ohdoi C., Yamagishi H., Murano H. and Ikeda T. Cell Prolif., 34:211-222, 2001. (124) Temperature dependence in proliferation of tetraploid Meth-A cells in comparison with the parent diploid cells. Fujikawa-Yamamoto K., Wang S., Yamagishi H. and Miyagoshi M. Cell Struct. Funct., 26:263-268, 2001. (125) Cell cycle response of diploid and tetraploid Meth-A cell lines to hydroxyurea. Fujikawa K., Miyakoshi M., Wang S. and Yamagishi H. Ann. Rep. Med. Res. Inst. Kanazawa Med. Univ., 12: 80-88, 2001. (126) Serum dependence in proliferation of diploid and tetraploid Meth-A cells. Fujikawa-Yamamoto K., Ikeda T., Wang S., Yamagishi H. and Miyagoshi M. Cytologia, 67:75-82, 2002. (127) Establishment of a triploid V79 cell line from tetraploid cells obtained through polyploidization using K-252a. Fujikawa-Yamamoto K., Yamagishi H., Wang S., and Miyagoshi M. Cell Prolif., 35:369-379, 2002. (128) Centrosome hyperamplification and chromosomal instability in bladder cancer. Kawamura K., Ozaki M., Fujikawa-Yamamoto K., Moriyama M., Domiki C., Suga K., Shiba N., Tanaka T., Ikeda R. and Suzuki K. J. Kanazawa Med. Univ., 27: 237-242, 2002. . 2003 Kanazawa Medical University, graduate school, professor (Res. Inst. of Med. Sci., division of Cell Medicine) 56 (129) Octaploid Meth-A cells are established from highly polyploidized cell population. Fujikawa-Yamamoto K., Yamagishi H., and Miyagoshi M. Cell Prolif., 36: 87-100, 2003. (130) Centrosome hyperamplification and chromosomal instability in bladder cancer. Kawamura K, Moriyama M, Shiba N, Ozaki M, Tanaka T, Nojima T, Fujikawa-Yamamoto K, Ikeda R, Suzuki K. Eur. Urol., 43: 505-15, 2003. (131) Maintenance of quantity and density of membrane glycochains in diploid-tetraploid and tetraploid-octaploid transitions, respectively of Meth-A cells demonstrated by lectin binding. Fujikawa-Yamamoto K. and Sakuma M. Cytologia, 68:191-198, 2003. (132) Variation of lectin binding with changes of ploidy in Meth-A cells. Sakuma M. and Fujikawa-Yamamoto K. Cytometry Res., 13: 39-44, 2003. (133) Effect of hydrochloric acid on the proliferation of tetraploid Meth-A cells. Fujikawa-Yamamoto K., Miyagoshi M. and Yamagishi H. Cytometry Res., 13:19-24, 2003. (134) The growth of diploid and tetraploid Meth-A cells in co-cultures at low temperature. Miyagoshi M., Fujikawa-Yamamoto K., and Yamagishi H. J. Kanazawa Med. Univ., 28: 69-73, 2003. (135) A fractal structure of the nucleus and its reproduction: A hypothesis (A fractal-like geometry of the nucleus and its reproduction: A hypothesis) Fujikawa-Yamamoto K. (Original author: Manabu Takahashi) Publication department of Kanazawa Med. Univ., pp1-190, Uchinada、2004. (translated book) (136) An approach to polyploid cells. Fujikawa-Yamamoto K. Publication department of Kanazawa Med. Univ., pp1-112, Uchinada、2004. (book) (137) Studies for establishment of polyploidized-cultured cells and transformation through polyploidization. Fujikawa k. Research Report to the Ministry of education (C) (2)、pp1-64, 2004. (Report) (138) Phorbol myristate induces apoptosis of taxol-resistant sarcoma cells in vitro. Zong ZP., Matsui S., Katsuda S, Han JF. and Fujikawa-Yamamoto K. Eur. J. Pharmacol., 489: 3-11, 2004. (139) Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpression. Kawamura K., Izumi H., Ma Z., Ikeda R., Moriyama M., Tanaka T., Nojima T., Levin L., Fujikawa-Yamamoto K., Suzuki K. and Fukasawa K. Cancer Res., 64:4800-4809, 2004. (140) Production of polyploid Meth-A cells whose ploidy is not a power of 2 by staurosporine. Fujikawa-Yamamoto K., Yamagishi H. and Miyagoshi M. Cytologia, 69:341-349, 2004. (141) Ploidy transformation of triplid V79 cells with demecolcine. Miyagoshi M., Fujikawa-Yamamoto K. and Yamagishi H. Cytometry Res., 14:51-56, 2004. (142) Centrosome hyperamplification and chromosomal damage after exposure to radiation. Kawamura K., Fujikawa-Yamamoto K., Ozaki M., Iwabuchi K., Nakashima H., Domiki C., Morita, N., Inoue N., Tokunaga K., Shiba N., Ikeda R and Suzuki K. Oncology, 67: 460-470, 2004. (143) Polyploidization of tetraploid Meth-A cells by staurosporine. Fujikawa-Yamamoto K., Miyagoshi M. and Yamagishi H. Cytometry Res., 15: 27-33, 2005. (144) DNA loss and related alterations in long-term cultures of diploid, tetraploid and octaploid Meth-A cells. Fujikawa-Yamamoto K., Miyagoshi M. and Yamagishi H. Cytologia, 70: 337-344, 2005. (145) Cell cycle analysis using flow cytometry. Fujikawa-Yamamoto K., Miyagoshi M. and Yamagishi H. J. Kanazawa Med. Univ., 30: 288-296, 2005. (146) An hypothesis about genome structures in mammalian polyploid cells based on a new concept that genome is fractal of six hierarchies. Fujikawa-Yamamoto K. Med. Hypotheses, 66: 337-344, 2006. (147) Cell cycle analysis using flow cytometry I. -Relationship between the fraction and the duration-. Fujikawa-Yamamoto K. and Miyagoshi M. Cytometry Res., 16: 33-36, 2006. (148) Cell cycle analysis using flow cytometry II. -BrdU continuous labeling and cell cycle time-. Fujikawa-Yamamoto K. and Miyagoshi M. Cytometry Res., 16: 37-41, 2006. (149) Cell cycle analysis using flow cytometry III. -Stathomokinetic analysis-. <<Source program>> Fujikawa-Yamamoto K. and Miyagoshi M. Cytometry Res., 16: 43-49, 2006. (150) The reversion to diploid cells from established triploid V79 cells. Miyagoshi M. and Fujikawa-Yamamoto K. Cell Prolif, 39: 421-428, 2006. (151) Induction of centrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure. Kawamura k., Morita N., Domiki C., Fujikawa-Yamamoto K., Hashimoto M, Iwabuchi K and Suzuki K. Cancer Sci, 97: 252-258, 2006. (152) Reversible alteration in morpholoby and proliferation of mouse H-1 (ES) cells in DME versus L15F10 medium. Fujikawa-Yamamoto K, Miyagoshi M. and Yamagishi H. J Kanazawa Med Univ, 31: 138-143, 2006. (153) Polyploidization of mouse H-1 (ES) cells by demecolcine and K-252a. Fujikawa-Yamamoto K, Miyagoshi M. and Yamagishi H. Cytologia, 71: 399-406, 2006. (154) Establishment of a tetraploid cell line from mouse H-1 (ES) cells highly polyploidized with demecolcine. Fujikawa-Yamamoto K, Miyagoshi M. and Yamagishi H. Cell Prolif, 40: 327-337, 2007. (155) Polyploidization of 2nH-1 (ES) cells by K-252a and staurosporine. Fujikawa-Yamamoto K, Miyagoshi M and Yamagishi H. Human Cell, 20: 91-99, 2007. (156) A hypothesis for the fractal structure of mammalian genome. I - Construction of hypothesis - Fujikawa-Yamamoto K J Kanazawa Med Univ, 32: 89-95, 2007. (review) (157) A hypothesis for the fractal structure of mammalian genome. II - Genome structure of polyploid cells - Fujikawa-Yamamoto K J Kanazawa Med Univ, 32: 96-101, 2007. (review) (158) A The establishment of tetraploid V79 cells using demecolcine. Miyagoshi M, Fujikawa-Yamamoto K and Yamagishi H J Kanazawa Med Univ, 32: 96-101, 2007. (159) Alteration and preservation of cellular characteristics in long-term culture of tetraploid H-1 (ES) cells. Fujikawa-Yamamoto K, Miyagoshi M, Yamagishi H and Luo X.. Human Cell, 18-27, 2008. (160) A new hypothesis for the genome structure of mammalian cells. I - A fractal sturucture model - Fujikawa-Yamamoto K Cytometry Res, 18: 57-64, 2008. (review) (161) A new hypothesis for the genome structure of mammalian cells. II - Development to polyploid cells - Fujikawa-Yamamoto K Cytometry Res, 18: 65-71, 2008. (review) (162) Cell proliferation of diploid and tetraploid H1(ES) cells in L15F10 medium without leukemia inhibitory factor. Fujikawa-Yamamoto K, Miyagoshi M, Yamagishi H and Luo X. Cytologia, 73: 259-268, 2008. (163) Tetraploid-diploid transition of tetraploid H1(ES) cells in L15F10 medium without leukemia inhibitory factor. Luo X, Fujikawa-Yamamoto K, Miyagoshi M and Yamagishi H. J Kanazawa Med Univ, 33: 107-111, 2008. (164) Gidelines for flow cytometrric analysis of DNA aneuploidy Takamoto S, Tsurusawa M, Nakauchi H, Nakahara K, Higashi K, Fujikawa-Yamamoto K, Murakami T and Watanabe T Cytometry Res, 19: 1-9, 2009. (topic review). (165) Cell cycle, morphology and pluripotency of octaploid embryonic stem cells in comparison with those of tetraploid and diploid cells. Fujikawa-Yamamoto K, Miyagoshi M and Yamagishi H. Human Cell, 22: 64-71, 2009. (166) Evaluation of sub-G1 peak in mitotic catastrophe. Kawamura K and Fujikawa-Yamamoto K. Cytometry Res., 19:63-71, 2009.(review). (167) DNA stable pentaploid H1(ES) cells obtained from an octaploid cell induced from tetraploid cells polyploidized using demecolcine. Fujikawa-Yamamoto K, Luo X, Miyagoshi M and Yamagishi H. J Cell Physiol, 223: 369-375, 2010. (168) Log channel DNA histograms Fujikawa-Yamamoto K Cytometry Res, 20: 57-63, 2010. (review) (169) Different responses between diploid and tetraploid H1 (ES) cells appeared during long-term culturing in L15F10 medium without leukemia inhibitory factor. Luo X, Fujikawa-Yamamoto K, Miyagoshi M and Yamagishi H. Human Cell, 23: 134-140, 2010. (170) DNA-unstable decaploid mouse H1 (ES) cells established from DNA-stable pentaploid H1 (ES) cells polyploidized using demecolcine. Fujikawa-Yamamoto K, Miyagoshi M, Luo X and Yamagishi H Cell Prolif, 44: 111-119, 2011. (171) Hexaploid H1 (ES) cells established from octaploid H1 cells are as DNA stable as pentaploid H1 cells. Fujikawa-Yamamoto K, Miyagoshi M, Luo X and Yamagishi H Human Cell, 24: 13-20, 2011. (172) Haploid unit-ploidy transition of tetraploid and octaploid H1 (ES) cells in long-term culturing. Fujikawa-Yamamoto K, Miyagoshi M, Yamagishi H and Ota T. Human Cell, 24: 78-85, 2011. (173) Pluripotency of a polyploid H1 (ES) cell system without leukemia inhibitory factor. Fujikawa-Yamamoto K, Ota T, Miyagoshi M and Yamagishi H. Cell Prolif, 45: 140-147, 2012. (174) Effects of etoposide on the proliferation of hexapolyploid H1 (ES) cells. Fujikawa-Yamamoto K, Ota T, Miyagoshi M and Yamagishi H. Human Cell, 25: 45-50, 2012.
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Dodecaploid H1 embryonic stem
cells abolished pluripotency in L15F10 medium both with and without
leukemia inhibitory factor.
Fujikawa-Yamamoto K, Miyagoshi M and Yamagishi H.
Human Cell,
26: 97-104, 2013.
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