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H24年度　業績

●岡崎俊朗●
  1. Elodie Lafont, Kazuyuki Kitatani, Toshiro Okazaki and Bruno, Ségui Sphingomyelin Biosynthesis Modulates Cancer Cell Death and Growth Topics in Anti-Cancer Research, 454-481, 2012
  2. Takafumi Kawanami, Toshioki Sawaki, Tomoyuki Sakai, Miyuki Miki, Haruka Iwao, Akio Nakajima, Takuji Nakamura, Tomomi Sato, Yoshimasa Fujita, Masao Tanaka, Yasufumi Masaki, Toshihiro Fukushima, Yuko Hirose, Makoto Taniguchi, Naotoshi Sugimoto, Toshiro Okazaki, Hisanori Umehara. Skewed Production of IL-6 and TGFb by Cultured Salivary Gland Epithelial Cells from Patients with Sjo¨ gren’s Syndrome Plos One 7, Issue 10, e45689, October 2012
  3. Zama K., Mitsutake S., Watanabe K, Okazaki T., Igarashi Y., A sensitive cell-based method to screen for selective inhibitors of SMS1 or SMS2 using HPLC and a fluorescent substrate Chem. Physic. Lipids: 167(7), 760–768, 2012
  4. Makoto Taniguchi, Kazuyuki Kitatani, Tadakazu Kondo, Mayumi Hashimoto, Satoshi Asano, Akira Hayashi, Susumu Mitsutake, Yasuyuki Igarashi, Hisanori Umehara, Hiroyuki Takeya, Junzo Kigawa, and Toshiro Okazaki. Regulation of autophagy and its associated cell death by sphingolipid rheostat: reciprocal role of ceramide and sphingosine-1-phosphate in the mTOR pathway J. Biol. Chem., 287(47): 39898-39910, 2012
  5. N. Sugimoto, O. Shido, K. Matsuzaki, T. Ohno-Shosaku, Y. Hitomi, M. Tanaka, T. Sawaki, Y. Fujita, T. Kawanami, Y. Masaki, T. Okazaki, H. Nakamura, S. Koizumi, A. Yachie, H. Umehara. Cellular heat acclimationregulates cell growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse fibroblast cells. Cellular Physiology and Biochemistry, 30(2): 450-7, 2012
  6. Mei-Hong Lu, Makoto Takemoto, Ken Watanabe, Huan Luo, Masataka Nishimura, Masato Yano, Hidekazu Tomimoto, Toshiro Okazaki, Yuichi Oike and Wen-Jie. Song Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice. J. Physiology 2012 May 28. [Epub ahead of print]
  7. Elodie Lafont, Romain Dupont, Nathalie Andrieu-Abadie, Toshiro Okazaki, Klaus Schulze-Osthoff, Thierry Levade, Hervé Benoist and Bruno Ségui Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis. Biochim. Biophys. Acta-Lipid 1821(4): 684-93, 2012
  8. L. Dong, K. Watanabe, M. Itoh, C-R. Huan, X-P. Tong, T. Nakamura, M. Miki, H. Iwao, A. Nakajima, T. Sakai, T. Kawanami, T. Sawaki, Y. Masaki, T. Fukushima, Y. Fujita, M. Tanaka, M. Yano, T. Okazaki and H. Umehara CD4+ T cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin synthase 1-knockout mice. Inter Immunol. 24: 327-337, 2012
  9. S. Asano, K. Kitatani, M. Taniguchi, M. Hashimoto, K. Zama, S. Mitsutake, Y. Igarashi, M. Takeya, R. Kigawa, A. Hayashi, H. Umehara and T. Okazaki Regulation of Cell Migration by Sphingomyelin Synthases: Sphingomyelin in Lipid Rafts Decreases Responsiveness to Signaling by the CXCL12/CXCR4 Pathway. Molecular and Cell Biology, 32(16):3242-52, 2012
●清川悦子●
  1. Mori Y., Yagi S., Sakurai A.,Matsuda M., Kiyokawa E*.: Insufficient ability of Rac1b to perturb cystogenesis. Small GTPases: in press
  2. Yagi S., Matsuda M., Kiyokawa E*.: Chimaerin suppresses Rac1 activation at the apical membrane to maintain the cyst structure. PLOS ONE., 7(12), e52258, 2012
  3. Sakurai A., Matsuda M., Kiyokawa E*.: Activated Ras protein accelerates cell cycle progression to perturb MDCK cystogenesis. J Biol Chem, 287(38), 31703-31711, 2012.
  4. Kamioka Y., Sumiyama K., Sakai Y., Mizuno R., Hirata E., Kiyokawa E., Matsuda M.:Live Imaging of Protein Kinase Activities in Transgenic Mice Expressing FRET Biosensors. Cell Struc. & Func., 37(1), 65-73, 2012
  5. Yagi S., Matsuda M., Kiyokawa E*.: Suppression of Rac1 Activity at the Apical Membrane of MDCK cells is Essential for Cyst Structure Maintenance. EMBO Rep: 13(3), 237-243, 2012.
●上田善道●
  1. Teppei Munehiro, Katsuhiko KItaoka, Yoshimichi Ueda, Yoshinobu Murahashi, Hiroyuki Tsuchiya: Establishment of an animal model for delayed onset muscle soreness after high-intensity eccentric exercise and its application for investigating the efficacy of low-load eccentric training. J Orthop Res　17:244-52, 2012
  2. T.Ichiseki, A. Kaneuji, Y.Ueda, S. Kaneko, S.Ueda, T.Matsumoto: The initial phase of oxidative stress in a　steroid-induced osteonecrosis rabbit model. Adv. Biosci Biotechnol 3: 978-82, 2012
  3. Katuo Usuda, Xi-Tong Zhao, Motoyasu Sagawa, Hirokazu Aikawa, Masakatsu Ueno, Makoto Tanaka, Yuichiro Machida, Munetaka Matoba, Yoshimichi Ueda, Tsutomu Sakuma: : Diffusion-weighted imaging 　(DWI) signal intensity and distribution represent the amount of cancer cells and their distribution in primary lung cancer. Clin Imaging. 37: 265-72, 2013
  4. Usuda K, Sagawa M, Motono N, Ueno M, Tanaka M, Machida Y, Matoba M, Kuginuki Y, Taniguchi M, Ueda Y,Sakuma T: Advantages of Diffusion-Weighted Imaging Over Positron Emission Tomography-Computed Tomography in Assessment of Hilar and Mediastinal Lymph Node in Lung Cancer. Ann Surg Oncol 20: 1676-83, 2013
  5. Satoshi Nishiike, Toshiaki Hiramatsu, Miharu Shiraishi, Yoshimichi Ueda, Hideaki Tsuchida: Relationship Between Vascular Reactivity And Expression of HMGB1 in a Rat Model of Septic Aorta. J　Anesthesia　(in press, 2013)
  6. 町田雄一郎、上田　善道、上野正克、田中良、相川広一、薄田勝男、佐川元保、佐久間勉：　肺腺癌の進展におけるアクアポリンの役割．肺癌 52: 17-22, 2012
  7. 山下　要、石川大輔、南條成輝、竹内伸司、山田忠明、毛利久継、大坪公士郎、安本和生、熊谷将史、上田善道、矢野星二：Cisplatin / irinotecan併用療法が有効であった大腸原発小細胞癌、多発性肝転移の1例. 癌と化学療法　39:1427-36, 2012
●加藤伸郎●
  1. Q.Zhang, K.Tanaka, P.Sun, M.Nakata, R.Yamamoto, K.Sakimura, M.Matsui, N.Kato. Suppression of synaptic plasticity by cerebrospinal fluid from anti-NMDA receptor encephalitis patients. Neurobiol. Dis. 45:610-615.
  2. T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato. Multimodal cross-talk of olfactory and gustatory information in the 　endopiriform nucleus in rats. Chem. Senses 37:681-688.
  3. I.Nomura, H.Takechi, N.Kato. Intraneuronally injected amyloid beta inhibits long-term potentiation in rat　　　hippocampal slices. J. Neurophysiol. 107:2526-2531.
  4. R.Yamamoto, Y.Ueta, T.Sugai, N.Kato. A serotonergic discrimination favoring synaptic inputs that accompany robust spike firing in lateral amygdala neurons. Neuroscience 220:119-13
●小坂健夫●
  1. M.Noguchi, M.Noguchi, Y.Nakano, Y.Ono, T.Kosaka：Axillary reverse mapping using a fluorescence imaging system in breast cancer，J. Surg. Oncol.，105:229-234，2012.
  2. Katsuhito Miyazawa, Yoshitaka Takahashi, Nobuyo Morita, Manabu T Moriyama, Takeo Kosaka, Matomo Nishio, Tanihiro Yoshimoto, Koji Suzuki：Cyclooxygenase 2 and prostaglandin E2 regulate the　attachment of calcium oxalate crystals to renal epithelial cells，Int. J. Urol.，19：936-943，2012.
  3. M.Noguchi, Y.Nakano, M.Noguchi, Y.Ono, T.Kosaka：Local therapy and survival in breast cancer with distant metastases，J. Surg. Oncol.，105:104-110，2012.
  4. M.Noguchi：Is axillary dissection unnecessary in patients with a positive sentinel lymph node?，Breast Cancer.，19:279-281，2012.
  5. 大野由夏子, 木南伸一, 甲斐田大資, 大西敏雄, 富田泰斗, 野口美樹, 舟木　洋, 表　和彦, 上田順彦, 中野泰治,野口昌邦,小坂健夫, 黒瀬　望：乳房内のセンチネルリンパ節に転移を認めた1例，北陸外科会誌，30:27-29，2011.
  6. 富田泰斗, 表　和彦, 木南伸一, 甲斐田大資, 大西敏雄, 大野由夏子, 野口美樹, 舟木　洋, 上田順彦, 中野泰治,小坂健夫：TS-1が奏効した空腸腺癌の一例，北陸外科会誌，30:31-33，2011.
  7. 上田順彦, 森岡絵美, 甲斐田大資, 富田泰斗, 大西敏雄, 大野由夏子, 野口美樹, 舟木　洋, 木南伸一, 表　和彦,中野泰治, 小坂健夫, 中田聡子, 湊　宏, 高村博之：薬剤耐性再発GISTに対して肝・横隔膜合併腫瘍切除した1例，癌と化療，39:2438-2440，2012.
  8. 大西敏雄, 木南伸一, 森岡絵美, 甲斐田大資, 大野由夏子, 富田泰斗, 野口美樹, 舟木　洋, 表　和彦, 中野泰治,上田順彦, 小坂健夫：大動脈周囲リンパ節再発に対しCPT-11+CDDP療法が奏効した胃原発神経内分泌細胞癌の1治験例，癌と化療，39:2384-2386，2012.
  9. 森岡絵美, 大野由夏子, 野口美樹, 中野泰治, 野口昌邦, 小坂健夫, 高仲　強：局所療法（外科的切除とSBRT）と全身療法により長期生存が得られた乳癌再発症例，癌と化療，39:1942-1944，2012.
  10. 富田泰斗, 森岡絵美, 甲斐田大資, 大西敏雄, 大野由夏子, 野口美樹, 舟木　洋, 木南伸一, 表　和彦, 中野泰治,上田順彦, 野口昌邦, 小坂健夫：盲腸癌肺転移術後の胸腔鏡ポートサイト再発を切除した1例，癌と化療，39:1923-1925，2012.
●元雄良治●
  1. Kitano A, Shimasaki T, Chikano Y, Nakada M, Hirose M, Higashi T, Ishigaki Y, Endo Y, Takino T, Sato H, Sai Y, 　　Miyamoto K, Motoo Y, Kawakami K, Minamoto T. Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy. PLoS One 8(2):e55289, 2013.
  2. Nakaya N, Ishigaki Y, Nakajima H, Murakami M, Shimasaki T, Takata T, Ozaki M, Dusetti NJ, Iovanna JL, Motoo Y. Meaning of tumor protein 53-induced nuclear protein 1 in the molecular mechanism of gemcitabine sensitivity, Mol Clin Oncol 1 :100-104, 2013.
  3. Takata T, Ishigaki Y, Shimasaki T, Tsuchida H, Motoo Y, Hayashi A Tomosugi N. Characterization of proteins secreted by pancreatic cancer cells with anticancer drug treatment in vitro. Oncol Rep 28(6): 1968-1976, 2012.
  4. Nakajima H, Koizumi K, Tanaka T, Ishigaki Y, Yoshitake Y, Yonekura H, Sakuma T, Fukushima T, Umehara H, Ueno S, Minamoto T, Motoo Y. Loss of HITS(FAM107B) expression in cancers of multiple organs: tissue microarray analysis. Int J Oncol 41: 1347-1357, 2012.
  5. Okada G, Watanabe H, Ohtsubo K, Mouri H, Yamaguchi Y, Motoo Y, Sawabu N. Multiple factors influencing the release of hTERT mRNA from pancreatic cancer cell lines in in vitro culture. Cell Biol Int 36(6): 545-53, 2012. Motoo Y. Traditional Japanese medicine in the multidisciplinary approach to cancer. J Trad Med 29(2): 104-107, 2012.
  6. Sato I, Nakaya N, Shimasaki T, Nakajima H. Motoo Y. Prediction of docetaxel monotherapy-induced neutropenia based on the monocyte percentage. Oncol Lett 3(4): 860-864, 2012.
  7. Fukushima T, Sato T, Nakamura T, Iwao H, Nakajima A, Miki M, Sakai T, Kawanami T, Sawaki T, Fujita Y, Tanaka M, Masaki Y, Okazaki T, Nakajima H, Motoo Y, Umehara H. Daily 500 mg Valacyclovir Is Effective for prevention of varicella zoster virus reactivation in patients with multiple myeloma treated with bortezomib. Anticancer Res. 2012 Dec;32(12):5437-40.
  8. Shimasaki T, Kitano A, Motoo Y, Minamoto T. Aberrant glycogen synthase kinase 3β in the development of pancreatic cancer. J Carcinog. 11(1):15, 2012. doi: 10.4103/1477-3163.100866. Epub 2012 Sep 13.
  9. 元雄 良治. 特集 消化管疾患に対する漢方医学からのアプローチ-現状と展望-: 消化管疾患に対する漢方医療の実際: (7)消化器癌に対する補助療法 ｂ. 全身状態改善とがん化学療法副作用軽減. 臨床消化器内科, 28(2): 215-220, 2013.
  10. 元雄 良治. 和漢医薬学とがん: 集学的・全人的がん医療における和漢医薬学の役割．漢方医薬学雑誌, 20(3): 16-17, 2013.
  11. 島崎 猛夫. 石垣 靖人. 高田 尊信. 川上 和之. 上田 順彦. 友杉 直久, 小坂 健夫, 源 利成, 元雄 良治. GSK3β標的治療と化学療法を併用する膵がんの新規治療戦略と分子基盤. 膵臓 27(3): 469, 2012.
●中村晃●
  1. Yoshiya Mitsuhashi, Akira Nakamura, Shota Endo, Kazuya Takeda, Toshiki Yabe-Wada, Toshihiro Nukiwa, Toshiyuki Takai (correspondence author): Regulation of plasmacytoid dendritic cell responses by PIR-B. Blood 120: 3256-3259 (2012)
  2. Won Fen Wong, Kazuyoshi Kohu, Akira Nakamura, Masahito Ebina, Toshiaki Kikuchi, Ryushi Tazawa, Keisuke Tanaka, Shunsuke Kon, Tomo Funaki, Akiko Sugahara-Tobinai, Chung Yeng Looi, Shota Endo, Ryo Funayama, Mineo Kurokawa, Sonoko Habu, Naoto Ishii, Manabu Fukumoto, Koh Nakata,Toshiyuki Takai and Masanobu Satake: Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells. Journal of Immunology 188: 5408-5420 (2012)
●竹上勉●
  1. Shimasaki T, Ishigaki Y, Nakamura Y, Takata T, Nakaya N, Nakajima H, Sato I, Zhao X, Kitano A, Kawakami K, Tanaka T, Takegami T, Tomosugi N, Minamoto T, Motoo Y: Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine. J Gastroenterol.47:321-333 2012.
  2. Nukuzuma S, Kameoka M, Sugiura S, Nakamichi K, Nukuzuma C, Miyoshi I, Takegami T: Exogenous Human Immunodeficiency Virus-1 Protein, Tat enhances replication of JC virus efficiently in neuroblastoma cell lines J Med Virol. 84: 555-561 2012
  3. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Sumida T, Mimori T, Tanaka Y, Tsubota K, Yoshino T, Kawa S, Suzuki R, Takegami T, Tomosugi N, Kurose N, Ishigaki Y, Azumi A, Kojima M, Nakamura S, Inoue D; The Research Program for Intractable Disease by Ministry of Health, Labor and Welfare (MHLW) Japan G4 team: A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details.Mod Rheumatol.22:1-14,2012
  4. Ishigaki Y, Nakamura Y, Oikawa Y, Yano Y, Kuwabata S, Nakagawa H, Tomosugi N, Takegami T: Observation of live ticks (Haemaphysalis flava) by scanning electron microscope under high vacuum pressure. PLoS One 7: e32676 (IF 4.41 ),2012
  5. Zhang S, Kim T-S, Dong Y, Kanazawa S, Kawaguchi M, Gao N, Minato H, Takegami T, Nojima T, Miura Y: AT motif binding factor 1 (ATBF1) is highly phosphorylated in embryonic brain and protected from cleavage by calpain-1 Biochem Biophys Res Commun 427: 537-541,2012
  6. Arikawa T, Simamura E, Shimada H, Nishi N, Tatsuno T, Ishigaki Y, Tomosugi N, Yamashiro C, Hata T, Takegami T, Mogami H, Yamaguchi K, Nakamura T, Otani H, Hatta T, Shoji H.: Expression pattern of Galectin 4 in rat placentation. Placenta 33: 885-887,2012
  7. Nukuzuma S, Kameoka M, Sugiura S, Nakamichi K, Nukuzuma C, Takegami T: Suppression of the PARP-1 Inhibitor on JC Virus Replication in vitro. J Med Virol,2012, Oct16 Published online (2012),（85:132-137,2013）