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これまでの業績

場所別に並べてみました。*印はCorresponding authorです。各々の末尾に総説・日本語の書き物があります。年代順はこちら。

金沢医大(2011-)

  1. Taniguchi K., Sugihara K., Miura T., Hoshi D., Kohno S., Takahashi C., Hirata E., Kiyokawa E*.: Cholesterol synthesis is essential for the growth of liver metastasis-prone colorectal cancer cells. Can Sci.: in press.
  2. Hoshi D*., Migita N., Ishizawa S., Sato Y., Yamamura K., Kiyokawa E.:Co-occurrence of Epstein-Barr virus-positive nodal T/NK-cell lymphoma and nodal T-follicular helper cell lymphoma of different clonal origins: An autopsy case report. Pathol Int.: 2024 Apr 5. doi: 10.1111/pin.13425. Online ahead of print.
  3. Kin R., Hoshi D., Fujita H., Kosaka T., Takamura H., Kiyokawa E*.:Prognostic significance of p16, p21 and Ki67 expression at the invasive front of colorectal cancers. Pathol Int.: 73(2), 81-90, 2023.
  4. Kiyokawa E*, Shoji H., Daikoku, T.:The suppression of DOCK family members by their specific inhibitors induces the cell fusion of human trophoblastic cells. Biochem Biophys Res Commun.: 529(4), 1173-1179, 2020.
  5. Aikawa A., Fujita H., Kosaka T., Minato H., Kiyokawa E*.: Clinicopathological significance of heterogeneic ezrin expression in poorly differentiated clusters of colorectal cancers. Can Sci.: 110(8), 2667-2675, 2019.
  6. Hirata E., Ichikawa T.,(Co-fast authors) Horike S., Kiyokawa E*.: Active K-RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro. Can Sci.: 109(12), 4045-4055, 2018. Selected as a cover.
  7. Xu X., Yoshizaki H.,(Co-fast authors) Ishigaki Y., Kubo E., Minato H., Kiyokawa E*.: Upregulation of multiple signaling pathways by Dock5 deletion in epithelial cells. Mol Vis.: 23: 1081-1092, 2017
  8. Takeda H., Kiyokawa E*.:Activation of Erk in ileal epithelial cells engaged in ischemic-injury repair. Sci Rep, 7(1):16469, 2017
  9. Yoshizaki H., Ogiso H., Okazaki T.,Kiyokawa E*.:Comparative lipid analysis in the normal and cancerous organoids of MDCK cells. J Biochem,159(6), 573-584, 2016
  10. Yoshizaki H., Kuwajima Y., Minato H.,Kiyokawa E*.:Regulation of Ripply1 expression in MDCK organoids. Biochem Biophys Res Commun.: 468(1-2):337-42, 2015
  11. Hirata E., Kiyokawa E*.: ERK activity imaging during migration of living cells in vitro and in vivo. Int J Mol Sci, 20(3): E679, 2019 [Review]
  12. Hirata E*., Kiyokawa E*.: Future Perspective of Single-Molecule FRET biosensors and Intravital FRET Microscopy. Biophys J, 111(6):1103-11, 2016 [Review]
  13. Minato H., Kiyokawa E*.: Activated K-RAS and its effect on morphological appearance. J Biochem, 156(3): 137-145, 2014 [Review]
  14. 星　大輔　清川悦子 「オルガノイドのライブイメージング」、谷口英樹　監修、オルガノイド研究　～培養・作製、活用、臨床応用～、株式会社　NTS, 2024
  15. 相川あかね　清川悦子 「Rhoファミリー」生体の科学　66(5), 404-405, 2015
  16. 清川悦子 「FRETバイオセンサーによって明らかとなった上皮構造維持における低分子量Gタンパク質Rac1の役割」 生化学　84(11), 947-951, 2012
  17. 清川悦子 「脂質の局在を可視化するFRETバイオセンサー」 金沢医科大学雑誌　37(2), 59-65, 2012

金沢医大(2011-)コラボ

  1. Shibata S., Shibata N., Otsuka S., Yoshitomi Y., Kiyokawa E., Yonekura H., Singh DP., Sasaki H., Kubo E.: Role of decorin in posterior capsule opacification and eye lens development. Cells: 9;10(4):863, 2021.
  2. Shibata T., Ikawa M., Sakasai R., Ishigaki Y., Kiyokawa E., Iwabuchi K., Singh DP., Sasaki H., Kubo E.: Lens–specific conditional knockout of Tropomyosin 1 gene in mice causes abnormal fiber differentiation and lens opacity. Mech Ageing Dev: 196:111492, 2021.
  3. Sugihara K., Yamaguchi Y., Usui S., Nashimoto Y., Hanada S Kiyokawa E., Uemura A., Yokokawa R., Nishiyama K., Miura T.: A new perfusion culture method with a self-organized capillary network. PLOS ONE.: 15(10):e0240552, 2020.
  4. Shibata N., Ishida H., Kiyokawa E., Singh DP., Sasaki H., Kubo E.: Relative gene expression analysis of human pterygium tissues and UV radiation-evoked gene expression patterns in corneal and conjunctival cells. Exp Eye Res.: 199:108194, 2020.
  5. Hirata E., Ishibashi K., Kohsaka S., Shinjo K., Kojima S., Kondo Y., Mano H., Yano S., Kiyokawa E., Sahai E.: The brain microenvironment induces DNMT1 suppression and indolence of metastatic cancer cells. iScience.: 23(9):101480, 2020
  6. Tominaga K., Minato H., Murayama T., Sasahara A.,Nishimura T., Kiyokawa E., Kanauchi H., Shimuzu S., Sato A., Nishioka K., Tsuji E., Yano M., Ogawa T., Ishii H., Mori M., Akashi K., Okamoto K., Tanabe M., Tada K., Tojo A., Gotoh N.:Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells. PNAS, 116(2):625-630, 2019
  7. Shibata T, Shibata S, Ishigaki Y, Kiyokawa E, Ikawa M, Singh DP, Sasaki H, Kubo E..: Tropomyosin 2 heterozygous knockout in mice using CRISPR-Cas9 system displays the inhibition of injury-induced epithelial-mesenchymal transition, and lens opacity. Mech Ageing Dev.: 171, 24-30, 2018
  8. Nishida S., Yoshizaki H.,Yasui Y., Kuwahara T.,Kiyokawa E., Kohno M.: Collagen VI suppresses fibronectin-induced enteric neural crest cell migration by downregulation of focal adhesion proteins. Biochem Biophys Res Commun.: 495(1):1461-1467, 2018
  9. Sasahara A., Tominaga K., Nishimura T., Yano M., Kiyokawa E., Noguchi M., Noguchi M., Kanauchi H., Ogawa T., Minato H., Tada K., Seto Y., Tojo A., Gotoh N.:An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells. Oncotarget,8(15):24869-24881, 2017
  10. Kubo E., Shibata S., Shibata T., Kiyokawa E., Sasaki H., Singh DP.:FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity. J Cell Mol Med., 21(5):916-928, 2017
  11. Shibata T., Shibata S., Shibata N., Kiyokawa E., Sasaki H., Singh DP., Kubo E.:Propolis, a Constituent of Honey, Inhibits the Development of Sugar Cataracts and High-Glucose-Induced Reactive Oxygen Species in Rat Lenses. J Ophthalmol., 1917093. 2016

大阪大学＆京都大学 (2004-2011)

  1. Kumagai Y., Naoki Y., Nakasho E., Kamioka, Y., Kiyokawa E, Matsuda M.: Heterogeneity in ERK activity as visualized by in vivo FRET imaging of mammary tumor cells developed in MMTV-Neu mice. Oncogene: 34(8): 1051-1057, 2015
  2. Mizuno R., KamiokaY., Kabashima K., Imajo M., Sumiyama K., Nakasho E., Ito T., Hamazaki Y., Okuchi Y., Sakai Y., Kiyokawa E., Matsuda M.: In vivo FRET imaging of activities of PKA and ERK during neutrophil recruitment to inflamed intestines. J Exp Med. 211(6):1123-36, 2014.
  3. Mori Y., Yagi S., Sakurai A.,Matsuda M., Kiyokawa E*.: Insufficient ability of Rac1b to perturb cystogenesis. Small GTPases:4(1) 9-15, 2013
  4. Yagi S., Matsuda M., Kiyokawa E*.: Chimaerin suppresses Rac1 activation at the apical membrane to maintain the cyst structure. PLOS ONE., 7(12), e52258, 2012.
  5. Sakurai A., Matsuda M., Kiyokawa E*.: Activated Ras protein accelerates cell cycle progression to perturb MDCK cystogenesis. J Biol Chem, 287(38), 31703-31711, 2012.
  6. Kamioka Y., Sumiyama K., Sakai Y., Mizuno R., Hirata E., Kiyokawa E., Matsuda M.:Live Imaging of Protein Kinase Activities in Transgenic Mice Expressing FRET Biosensors. Cell Struc. & Func., 37(1), 65-73, 2012
  7. Yagi S., Matsuda M., Kiyokawa E*.: Suppression of Rac1 Activity at the Apical Membrane of MDCK cells is Essential for Cyst Structure Maintenance. EMBO Rep: 13(3), 237-243, 2012.
  8. Kumagai Y., Kamioka, Y., Yagi S., Matsuda M., Kiyokawa E*.: A genetically encoded Forster resonance energy transfer (FRET) biosensor for two-photon excitation microscopy. Anal. Biochem. 413(2), 192-199, 2011.
  9. Nishioka T., Frohman, MA., Matsuda M., Kiyokawa E*.: Heterogeneity of Phosphatidic Acid Levels and Distribution at the Plasma Membrane in Living Cells as Visualized by a Forster Resonance Energy Transfer (FRET) Biosensor. J Biol Chem: 285 (46): 35979-35987, 2010.
  10. Yoshiki S., Udagawa R., Aoki K., Kamioka Y., Kiyokawa E., Matsuda M.: Ras and Calcium signaling pathways converge at Raf1 via the Shoc2 scaffold protein. Mol Biol Cell: 21 (6): 1088-1096, 2010.
  11. Matsunaga-Udagawa R., Fujita Y., Yoshiki S., Terai K., Kamioka Y., Kiyokawa E., Yugi K., Aoki K., Matsuda M.: The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf. J Biol Chem.: 285(10): 7818-7826, 2010.
  12. Tachibana M., Kiyokawa E*., Hara S., Iemura S., Natsume T., Manabe T., Matsuda M.: Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation. Exp. Cell Res. 315(5): 863-876, 2009.
  13. Itoh RE., Kiyokawa E., Aoki,K., Nishioka T., Akiyama T., Matsuda M.: Phosphorylation and activation of a Rac1/Cdc42 guanine nucleotide exchange factor Asef in A431 cells stimulated by epidermal growth factor. J. Cell Sci. 121 (16): 2635-2642, 2008.
  14. Nishioka T., Aoki K., Hikake K., Yoshizaki H., Kiyokawa E*., Matsuda M.: Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells. Mol Biol Cell 19(10): 4213-4223, 2008.
  15. Hara S., Kiyokawa E*., Iemura S., Natsume T., Wassmer T., Cullen PJ., Hiai H., Matsuda M.: The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport. Mol Biol Cell 19(9): 3823-3835, 2008.
  16. Omi N., Kiyokawa E., Matsuda M., Yamada S., Yamada K., Kinoshita K., Wang Y., Matsushima Y., Kawai J., Suzuki M., Hayashizaki Y., Hiai H.: Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse. Exp Eye Res., 86(5):828-34, 2008.
  17. Takaya A., Kamio T., Masuda M., Mochizuki N., Sawa H., Sato M., Nagashima K., Mizutani A., Matsuno A., Kiyokawa E., Matsuda M.: R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes. Mol Biol Cell 18 (5): 1850-1860, 2007.
  18. Kiyokawa E, Aoki K., Nakamura T, Matsuda M.: Spatiotemporal Regulation of Small GTPases as Revealed by Probes Based on the Principle of Förster Resonance Energy Transfer (FRET): Implications for Signaling and Pharmacology. Annu. Rev. Pharmacol. Toxicol., 51: 337-358, 2010. [Review]
  19. Kiyokawa E*., Matsuda M.: Regulation of focal adhesion and cell migration by ANKRD28-DOCK180 interaction. Cell Adh. Migr. 3 (3): 281-284, 2009. [Review]
  20. Nakamura T., Kurokawa K., Kiyokawa E., Matsuda M.: Analysis of the Spatio-Temporal Activation of Rho GTPases using Raichu Probes. Methods Enzymol. 406: 315-332, 2006. [Review]
  21. Kiyokawa E., Hara S, Nakamura T, Matsuda M.: Fluorescence (Förster) resonance energy transfer imaging of oncogene activity in living cells. Cancer Sci. 97(1):8-15, 2006. [Review]
  22. 清川悦子　松田道行　「細胞内シグナルのin vivoイメージング」 病理と臨床　30(7), 712-718, 2012
  23. 水野礼　清川悦子　松田道行　「FRETによる細胞シグナルの分子イメージング」最新医学　66巻（通巻841号）　特集「分子イメージングの最先端」 2376-2383, 2011.
  24. 清川悦子　上岡裕治　松田道行　「癌のFRETライブイメージング」Surgery Frontier 18(1) 2011.
  25. 清川悦子　八木俊輔　松田道行　「Small Gタンパク質活性化の時空間情報を取得する」細胞工学　28(12), 1229-1233, 2009.
  26. 清川悦子　松田道行　「腫瘍をめぐるQ&A　分子イメージングについて教えてください」Surgery Frontier 16(4)　98-100, 2009.
  27. 清川悦子　松田道行　「シグナル伝達カスケードの生細胞イメージング」　Annual Review 「免疫」 303-312, 2008
  28. 清川悦子　松田道行　「細胞内イメージング　（FRETなど）」　遺伝子医学MOOK　9号　「ますます広がる分子イメージング技術」, 120-125, 2008
  29. 原重雄　清川悦子　松田道行　「癌遺伝子情報伝達系イメージング」 病理と臨床　25(6), 560-565, 2007

理研(2000-2004)

  1. Kiyokawa E*., Baba T., Otsuka N., Makino A., Ohno S., Kobayashi T*.: Spatial and functional heterogeneity of sphingolipid-rich membrane domains. J Biol Chem. 280(25):24072-84, 2005.
  2. Kiyokawa E., Makino A., Ishii K., Otsuka N., Yamaji-Hasegawa A., Kobayashi T.: Recognition of sphingomyelin by lysenin and lysenin-related proteins, Biochemistry 43, 9766-9773, 2004
  3. Yamaji-Hasegawa A, Makino A, Baba T, Senoh Y, Kimura-Suda H, Sato SB, Terada N, Ohno S, Kiyokawa E, Umeda M, Kobayashi T.: Oligomerization and pore formation of a sphingomyelin-specific toxin, lysenin. J Biol Chem. 278(25):22762-70, 2003.
  4. Kobayashi T., Yamaji-Hasegawa A. Kiyokawa E.: Lipid domains in the endocytic pathway. Sem. Cell Dev. Biol. 12(2), 173-82, 2001. [Review]
  5. 清川悦子　「スフィンゴ脂質の自己組織化と細胞機能」　バイオニクス　2(3), 74-75, 2005

ジュネーブ大(1998-2000)

  1. Guyader M., Kiyokawa E., Abrami L., Turelli P., Trono D.: Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization. J Virol. 76(20):10356-64, 2002.
  2. Vilhardt F, Plastre O., Sawada M., Suzuki K., Wiznerowicz M., Kiyokawa E., Trono D., Krause KH.: The HIV-1 Nef protein and phagocyte NADPH oxidase activation. J Biol Chem. 277(44):42136-43, 2002
  3. Wang JK., Kiyokawa E., (The first two equally contributed) Verdin E., Trono D.: The Nef protein of HIV-1 associates with raft and primes T cells for activation. Proc. Natl. Acad. Sci. USA 97(1), 394-399, 2000.
  4. 清川悦子　「HIV-1のアクセサリ分子NefとT細胞活性化」　生化学　72(11), 1337-1340, 2000.

感染研(1995-1998)

  1. Tobiume M., Tokunaga K., Kiyokawa E., Takahoko M., Mochizuki N., Tatsumi, M., Matsuda, M.: Requirement of nef for HIV-1 infectivity is biased by the expression levels of Env in the virus-producing cells and CD4 in the target cells. Arch Virol. 146(9), 1739-51, 2001.
  2. Kobayashi S., Shirai T., Kiyokawa E., Mochizuki N., Matsuda M., Fukui Y.: Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3. Biochem J. 354 (1):73-8, 2001.
  3. Katayama H., Hashimoto Y., Kiyokawa E., Nakaya M., Sakamoto A., Machinami R., Kurata T., Mochizuki N., Matsuda M.: Epidermal growth factor-dependent dissociation of CrkII proto-oncogene product from the epidermal growth factor receptor in human glioma cells. Jpn. J. Cancer Res. 90(10), 1096-1103, 1999.
  4. Mochizuki N., Ohba Y., Kiyokawa E., Kurata T., Murakami T., Ozaki, T., Kitabatake A., Nagashima K., Matsuda M.: Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Gi. Nature 400, 891-894, 1999.
  5. Hashimoto Y., Katayama H., Kiyokawa E., Ota S., Kurata T., Gotoh N., Otsuka N., Shibata M., Matsuda M.: Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor. J Biol Chem. 273 (27): 17186-17191, 1998
  6. Tokunaga K., Kiyokawa E., Nakaya M.,Otsuka N., Kojima A., Kurata T., Matsuda M.: Inhibition of Human Immunodeficiency Virus Type-1 Virion Entry by Dominant Negative Hck. J Virol. 72 (7): 6257-6259, 1998.
  7. Kiyokawa E., Hashimoto Y., Kobayashi S., Sugimura H., Kurata T., Matsuda M.: Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev. 12 (21): 3331-3336, 1998
  8. Kiyokawa E., Hashimoto Y., Sugimura H., Kurata T., Matsuda M.: Evidence that DOCK180 up-regulates signals from the Crk-p130Cas complex. J Biol Chem. 273 (38): 24479-24484, 1998.
  9. Takai S., Hasegawa H., Kiyokawa E., Yamada K., Kurata T., Matsuda M.: Chromosomal mapping of the gene encoding DOCK 180, a major Crk-binding protein, to 10q26.13-q26.3 by fluorescence in situ hybridization. Genomics 35 (2): 403-404, 1996.
  10. Hasegawa H., Kiyokawa E., Tanaka S., Nagashima K., Gotoh N., Kurata T., Matsuda M.: DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the membrane. Mol Cell Biol. 16 (4), 1770-1776, 1996.
  11. Kiyokawa E., Mochizuki N., Kurata T., Matsuda M.: Role of Crk Oncogene product in physiologic signaling. Crit Rev Oncogenesis 8 (4): 329-342, 1997.[Review]
  12. 清川悦子　松田道行　「Crk」 Bio Science 用語ライブラリー　癌遺伝子・癌抑制遺伝子　46-47, 1997

浜松医大(1993-1995)

  1. Xiang Y.-Y., Wang D.-Y., Suzuki M., Kiyokawa E., Igarashi H., Naito Y., Shen Q., Sugimura H.: Expression of High Mobility Group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding noncancerous mucosa. Int J Cancer 74 (1), 1-6, 1997.
  2. Kasami M, Yoshida M, Isogaki J, Ogawa H, Shinmura K, Endo Y, Kiyokawa E, Naito Y, Arai T, Kimura T, Inoue R, Sugimura H.: Bilateral breast tumors, malignant phyllodes tumor and invasive lobular carcinoma in a 46,XX/46,XY mosaic female with family history of breast cancer. Pathol Int., 47(2-3):147-54, 1997.
  3. Sugimura H., Hamada GS., Suzuki I., Iwase T., Kiyokawa E., Kino I., Tsugane S.: CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil. Pharmacogenetics., 5: S145-148. 1995.
  4. Hamada GS., Sugimura H., Suzuki I., Nagura K., Kiyokawa E., Iwase T., Tanaka M., Takahashi T, Watanabe S., Kino I., Tsugane S.: The heme-binding region polymorphism of cytochrome P450IA1 (CypIA1), rather than the RsaI polymorphism of IIE1 (CypIIE1), is associated with lung cancer in Rio de Janeiro. Cancer Epidemiol Biomarkers Prev. 4(1):63-67, 1995.
  5. Kiyokawa E., Takai S., Tanaka M., Iwase T., Suzuki M., Xiang YY., Naito Y, Yamada K., Sugimura H., Kino I.: Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors. Cancer Res. 54(14):3645-50, 1994.
  6. Xiang YY., Tanaka M., Suzuki M, Igarashi H, Kiyokawa E., Naito Y., Ohtawara Y, Shen Q., Sugimura H., Kino I.: Isolation of complementary DNA encoding K-cadherin, a novel rat cadherin preferentially expressed in fetal kidney and kidney carcinoma. Cancer Res. 54(11):3034-41, 1994.